| http://purl.uniprot.org/citations/20043075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20043075 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified an 8-gene signature with significant expression differences between gastric cancer and normal gastric tissues. This 8-gene set can predict the normal and cancer status of gastric tissues with more than 96% accuracy in a totally independent microarray dataset. The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer. To corroborate the differential gene expression pattern, we chose GPX3 and examined its expression pattern in detail. A comparison of GPX3 expression pattern shows a broader down-regulated pattern in multiple types of cancers, including cervical, thyroid, head and neck, lung cancers and melanoma than in healthy controls. An immuno-histostaining analysis in tissue microarrays confirms GPX3 down-regulation in gastric cancer. Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers."xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/author | "Kim K.Y."xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/author | "Yang J.J."xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/author | "Ahn W.S."xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/name | "Int J Oncol"xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/pages | "405-414"xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/title | "An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/20043075 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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