| http://purl.uniprot.org/citations/20043097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20043097 | http://www.w3.org/2000/01/rdf-schema#comment | "The metastasis of malignant tumor cells from the primary tumor to distant sites in the body is a complex process. To identify genes that may be essential for metastasis, we established poorly metastatic mouse melanoma cells, namely Y925F-mutated FAK-transfected cells (Y925F cells), from the highly metastatic mouse melanoma cell line B16F10, and performed expression analyses. The expression of phospholipid protein 2 (PLP2) was markedly down-regulated in the Y925F cells. To elucidate the function of PLP2, we established melanoma cells overexpressing PLP2. We found that PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo. These results suggest that PLP2 aids metastasis. Furthermore, we showed that PLP2 binds specifically to PI3K, thus activating Akt."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/author | "Fukuda Y."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/author | "Sonoda Y."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/author | "Kasahara T."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/author | "Ozawa H."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/author | "Funakoshi-Tago M."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/author | "Warita M."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/pages | "371-376"xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/title | "Proteolipid protein 2 is associated with melanoma metastasis."xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/20043097 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20043097 |
| http://purl.uniprot.org/citations/20043097 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20043097 |
| http://purl.uniprot.org/uniprot/#_Q58E29-mappedCitation-20043097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20043097 |
| http://purl.uniprot.org/uniprot/#_Q0VEW4-mappedCitation-20043097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20043097 |
| http://purl.uniprot.org/uniprot/#_Q9R1Q7-mappedCitation-20043097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20043097 |
| http://purl.uniprot.org/uniprot/Q0VEW4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20043097 |
| http://purl.uniprot.org/uniprot/Q9R1Q7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20043097 |
| http://purl.uniprot.org/uniprot/Q58E29 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20043097 |