| http://purl.uniprot.org/citations/20043910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20043910 | http://www.w3.org/2000/01/rdf-schema#comment | "RKIP was first identified as an inhibitor of the Raf-MEK-ERK signaling pathway. RKIP was also found to play an important role in the NF-kappaB pathway. Genetic and biochemical studies demonstrated that RKIP functioned as a scaffold protein facilitating the phosphorylation of IkappaB by upstream kinases. However, contrary to what one would expect of a scaffold protein, our results show that RKIP has an overall inhibitory effect on the NF-kappaB transcriptional activities. Since NF-kappaB target gene expression is subject to negative regulation involving the optimal induction of negative regulators, our data support a hypothesis that RKIP inhibits NF-kappaB activity via the auto-regulatory feedback loop by rapidly inducing the expression and synthesis of inhibitors of NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2009.12.051"xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/author | "Ren G."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/author | "Sun S.C."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/author | "Yeung K.C."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/author | "Trumbly R."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/author | "Tsung E."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/pages | "662-668"xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/title | "RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex."xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://purl.uniprot.org/core/volume | "584"xsd:string |
| http://purl.uniprot.org/citations/20043910 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20043910 |
| http://purl.uniprot.org/citations/20043910 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20043910 |
| http://purl.uniprot.org/uniprot/#_A0A0K0K1J6-mappedCitation-20043910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20043910 |
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