| http://purl.uniprot.org/citations/20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20049876 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell immunoglobulin, mucin domain-3 (Tim-3) is a membrane protein expressed at late stages of IFN-gamma secreting CD4(+) Th1 cell differentiation and constitutively on DC. Ligation of Tim-3 on Th1 cells terminates Th1 immune responses. In addition, Tim-3 plays a role in tolerance induction, although the mechanism by which this is accomplished has yet to be elucidated. While it is clear that Tim-3 plays an important role in the immune system, little is known regarding the molecular pathways that regulate Tim-3 expression. In the current study, we examine the role of Th1-associated transcription factors in regulating Tim-3 expression. Our experiments reveal that Tim-3 expression is regulated by the Th1-specific transcription factor T-bet. This introduces a novel paradigm into the generation of a Th1 response, whereby a transcription factor responsible for effector Th1 cell differentiation also increases the expression of a specific counter-regulatory molecule to ensure appropriate termination of pro-inflammatory Th1 immune responses."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200939842"xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/author | "Lee D.H."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/author | "Anderson A.C."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/author | "Dardalhon V."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/author | "Glimcher L.H."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/author | "Lord G.M."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/author | "Sabatos-Peyton C.A."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/pages | "859-866"xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/title | "T-bet, a Th1 transcription factor regulates the expression of Tim-3."xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/20049876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20049876 |
| http://purl.uniprot.org/citations/20049876 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20049876 |
| http://purl.uniprot.org/uniprot/#_D3Z3I4-mappedCitation-20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20049876 |
| http://purl.uniprot.org/uniprot/#_Q5PSB0-mappedCitation-20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20049876 |
| http://purl.uniprot.org/uniprot/#_P42228-mappedCitation-20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20049876 |
| http://purl.uniprot.org/uniprot/#_Q3KP82-mappedCitation-20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20049876 |
| http://purl.uniprot.org/uniprot/#_Q3V157-mappedCitation-20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20049876 |
| http://purl.uniprot.org/uniprot/#_Q9JKD8-mappedCitation-20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20049876 |
| http://purl.uniprot.org/uniprot/#_Q3U098-mappedCitation-20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20049876 |
| http://purl.uniprot.org/uniprot/#_Q4G0C1-mappedCitation-20049876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20049876 |