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http://purl.uniprot.org/citations/20057160http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20057160http://www.w3.org/2000/01/rdf-schema#comment"

Background

Lipocalin-2/neutrophil gelatinase-B associated lipocalin (Lcn2/NGAL) is involved in the transport of iron and seems to play an important role in inflammation. A recent study has reported that it is also expressed in the failing heart and may be a biomarker not only for renal failure but also for heart failure. Because Lcn2/NGAL is thought to be induced by interleukin-1, it might be strongly induced in the presence of myocarditis.

Methods and results

This study investigated the expression of Lcn2/NGAL in rat experimental autoimmune myocarditis (EAM) and in human myocarditis. In EAM hearts, the expression of Lcn2/NGAL was markedly increased (>100-fold at an early stage), and in human myocarditis it was also highly expressed compared with non-inflammatory failing hearts. Lcn2/NGAL expressing cells in hearts with EAM and human myocarditis were identified as cardiomyocytes, vascular wall cells, fibroblasts and neutrophils. Lcn2/NGAL in EAM rats was also expressed in the liver. Plasma Lcn2/NGAL levels abruptly increased at an early stage of EAM, and high levels were initially sustained during the inflammatory stage, then decreased with recovery. In contrast, levels of B-type natriuretic peptide increased only slowly as the disease progressed.

Conclusions

Cardiomyocytes, vascular wall cells and fibroblasts in myocarditis strongly express Lcn2/NGAL via proinflammatory cytokines."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.org/dc/terms/identifier"doi:10.1253/circj.cj-09-0485"xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Ding L."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Yoshida T."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Yoshida K."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Watanabe R."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Ogura M."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Kodama M."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Ota Y."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Aizawa Y."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Toba K."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Hanawa H."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Hao K."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Hasegawa G."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/author"Asami F."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/name"Circ J"xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/pages"523-530"xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/title"Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis."xsd:string
http://purl.uniprot.org/citations/20057160http://purl.uniprot.org/core/volume"74"xsd:string
http://purl.uniprot.org/citations/20057160http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20057160
http://purl.uniprot.org/citations/20057160http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20057160
http://purl.uniprot.org/uniprot/P30152#attribution-33F7D36478E6517D441A5461B0D4253Ahttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/20057160
http://purl.uniprot.org/uniprot/#_B2ZDQ1-mappedCitation-20057160http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20057160
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