| http://purl.uniprot.org/citations/20059953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20059953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20059953 | http://www.w3.org/2000/01/rdf-schema#comment | "We created a whole-mount in situ hybridization (WISH) database, termed EMBRYS, containing expression data of 1520 transcription factors and cofactors expressed in E9.5, E10.5, and E11.5 mouse embryos--a highly dynamic stage of skeletal myogenesis. This approach implicated 43 genes in regulation of embryonic myogenesis, including a transcriptional repressor, the zinc-finger protein RP58 (also known as Zfp238). Knockout and knockdown approaches confirmed an essential role for RP58 in skeletal myogenesis. Cell-based high-throughput transfection screening revealed that RP58 is a direct MyoD target. Microarray analysis identified two inhibitors of skeletal myogenesis, Id2 and Id3, as targets for RP58-mediated repression. Consistently, MyoD-dependent activation of the myogenic program is impaired in RP58 null fibroblasts and downregulation of Id2 and Id3 rescues MyoD's ability to promote myogenesis in these cells. Our combined, multi-system approach reveals a MyoD-activated regulatory loop relying on RP58-mediated repression of muscle regulatory factor (MRF) inhibitors."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.10.011"xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.10.011"xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Hashimoto M."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Hashimoto M."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Hayashizaki Y."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Hayashizaki Y."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Ito Y."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Ito Y."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Yamashita S."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Yamashita S."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Mitsuoka K."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Mitsuoka K."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Nagai A."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Nagai A."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Puri P.L."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Puri P.L."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Kasai M."xsd:string |
| http://purl.uniprot.org/citations/20059953 | http://purl.uniprot.org/core/author | "Kasai M."xsd:string |