| http://purl.uniprot.org/citations/20059959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20059959 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for centrosome duplication. In Caenorhabditis elegans embryos, the proteins SPD-2, ZYG-1, SAS-6, SAS-5, and SAS-4 are essential for centriole formation, but the mechanisms underlying their requirement remain unclear. Here, we demonstrate that the kinase ZYG-1 phosphorylates the coiled-coil protein SAS-6 at serine 123 in vitro. Importantly, we show that this phosphorylation event is crucial for centriole formation in vivo. Furthermore, we establish that such phosphorylation ensures the maintenance of SAS-6 at the emerging centriole. Overall, our findings establish that phosphorylation of the evolutionarily conserved protein SAS-6 is critical for centriole formation and thus for faithful cell division."xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.11.002"xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/author | "Gonczy P."xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/author | "Busso C."xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/author | "Fluckiger I."xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/author | "Kitagawa D."xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/pages | "900-907"xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/title | "Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos."xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/20059959 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20059959 |
| http://purl.uniprot.org/citations/20059959 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20059959 |
| http://purl.uniprot.org/uniprot/Q9GT24#attribution-178E2CDB7B9DE2E11263A52A214D0188 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20059959 |
| http://purl.uniprot.org/uniprot/#_O01904-mappedCitation-20059959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20059959 |
| http://purl.uniprot.org/uniprot/#_O62479-mappedCitation-20059959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20059959 |
| http://purl.uniprot.org/uniprot/#_Q9GT24-mappedCitation-20059959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20059959 |
| http://purl.uniprot.org/uniprot/O62479 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20059959 |
| http://purl.uniprot.org/uniprot/O01904 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20059959 |
| http://purl.uniprot.org/uniprot/Q9GT24 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20059959 |