| http://purl.uniprot.org/citations/20060297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20060297 | http://www.w3.org/2000/01/rdf-schema#comment | "How are biological structures maintained in a cellular environment that constantly threatens protein integrity? Here we elucidate proteostasis mechanisms affecting the Z disk, a protein assembly essential for actin anchoring in striated muscles, which is subjected to mechanical, thermal, and oxidative stress during contraction [1]. Based on the characterization of the Drosophila melanogaster cochaperone Starvin (Stv), we define a conserved chaperone machinery required for Z disk maintenance. Instead of keeping Z disk proteins in a folded conformation, this machinery facilitates the degradation of damaged components, such as filamin, through chaperone-assisted selective autophagy (CASA). Stv and its mammalian ortholog BAG-3 coordinate the activity of Hsc70 and the small heat shock protein HspB8 during disposal that is initiated by the chaperone-associated ubiquitin ligase CHIP and the autophagic ubiquitin adaptor p62. CASA is thus distinct from chaperone-mediated autophagy, previously shown to facilitate the ubiquitin-independent, direct translocation of a client across the lysosomal membrane [2]. Impaired CASA results in Z disk disintegration and progressive muscle weakness in flies, mice, and men. Our findings reveal the importance of chaperone-assisted degradation for the preservation of cellular structures and identify muscle as a tissue that highly relies on an intact proteostasis network, thereby shedding light on diverse myopathies and aging."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.11.022"xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Saftig P."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Saint R."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Hoch M."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Hohfeld J."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Furst D.O."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Wenzel D."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Arndt V."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Dreiseidler M."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Hesse M."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Fleischmann B.K."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Dick N."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/author | "Tawo R."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/pages | "143-148"xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/title | "Chaperone-assisted selective autophagy is essential for muscle maintenance."xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/20060297 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20060297 |
| http://purl.uniprot.org/citations/20060297 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20060297 |
| http://purl.uniprot.org/uniprot/Q9JLV1#attribution-FD24E48C4077392F2034A6E9F1816998 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060297 |
| http://purl.uniprot.org/uniprot/Q9WUD1#attribution-FD24E48C4077392F2034A6E9F1816998 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060297 |
| http://purl.uniprot.org/uniprot/P63018#attribution-FD24E48C4077392F2034A6E9F1816998 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060297 |