| http://purl.uniprot.org/citations/20060382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20060382 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiopoietin-1 (Ang1) is a ligand for the endothelial-specific tyrosine kinase receptor Tie2 and has been shown to play an essential role in embryonic vasculature development. There have been many studies about the anti-inflammatory effects of Ang1, most of which focus on endothelium cells. In the present study, we explore the role of Ang1-Tie2 signaling in the activation of macrophages upon lipopolysaccharide (LPS) stimulation. We found that Tie2 receptor is expressed on macrophages and Ang1 could inhibit LPS-induced activation of macrophages, as evidenced by cell migration and TNF-alpha production, specifically through Tie2 receptor. We further investigated the mechanism and found that Ang1-Tie2 could block LPS-induced activation of NF-kappaB which has been shown to be necessary for macrophage activation with LPS treatment. Thus, we described, for the first time, the role of Ang1-Tie2 signaling in macrophage activation and the possible mechanisms in response to immune stimulation."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.01.009"xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/author | "Bai Y."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/author | "Gu H."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/author | "Ma K."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/author | "Zhou C."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/author | "Cui M."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/pages | "178-182"xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/title | "Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells."xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://purl.uniprot.org/core/volume | "392"xsd:string |
| http://purl.uniprot.org/citations/20060382 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20060382 |
| http://purl.uniprot.org/citations/20060382 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20060382 |
| http://purl.uniprot.org/uniprot/O08538#attribution-7B0B901609CC7A09A83FED5C1D67E901 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060382 |
| http://purl.uniprot.org/uniprot/O08538#attribution-B2F347AAF8E5B697FCB8E328EB53DFD4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060382 |
| http://purl.uniprot.org/uniprot/Q60778#attribution-B2F347AAF8E5B697FCB8E328EB53DFD4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060382 |
| http://purl.uniprot.org/uniprot/P25799#attribution-B2F347AAF8E5B697FCB8E328EB53DFD4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060382 |
| http://purl.uniprot.org/uniprot/Q02858#attribution-7B0B901609CC7A09A83FED5C1D67E901 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060382 |
| http://purl.uniprot.org/uniprot/Q02858#attribution-B2F347AAF8E5B697FCB8E328EB53DFD4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060382 |
| http://purl.uniprot.org/uniprot/P06804#attribution-B2F347AAF8E5B697FCB8E328EB53DFD4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20060382 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-20060382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20060382 |