| http://purl.uniprot.org/citations/20061393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20061393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20061393 | http://www.w3.org/2000/01/rdf-schema#comment | "The FOXO family of forkhead transcription factors has a variety of important functions in stress response, metabolism, cell cycle, apoptosis, longevity, etc. The transcriptional activity and subcellular localization of FOXO are tightly regulated by post-translational modifications, including phosphorylation by various kinases. Here, we report that the transforming growth factor-beta-activated kinase (TAK1)-Nemo-like kinase (NLK) pathway negatively regulates FOXO1. We show that NLK binds and phosphorylates FOXO1 at Pro-directed Ser/Thr residues in the transactivation domain. The phosphorylation by TAK1-NLK pathway inhibits the transcriptional activity of FOXO1 and excludes FOXO1 from the nucleus, which is independent of phosphatidylinositol 3-kinase/Akt pathway. Consistently, knockdown of TAK1-NLK pathway dephosphorylates FOXO1 and decreases phospho-Ser-329 FOXO1 level. It also induces translocation of FOXO1 into the nucleus and leads to an increase in mRNA levels of FOXO target genes and poly(ADP-ribose) polymerase cleavage. In addition, we show the interaction between NLK and FOXO1 is evolutionarily conserved in Drosophila. Collectively, these findings provide the first evidence that TAK1-NLK pathway is a novel regulator of FOXO1."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.101824"xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.101824"xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/pages | "8122-8129"xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/pages | "8122-8129"xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/title | "Regulation of FOXO1 by TAK1-Nemo-like kinase pathway."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/title | "Regulation of FOXO1 by TAK1-Nemo-like kinase pathway."xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20061393 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20061393 |
| http://purl.uniprot.org/citations/20061393 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20061393 |