| http://purl.uniprot.org/citations/20061547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20061547 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have implicated Toll-like receptor 2 (TLR2) and TLR4 signaling in delimiting liver and brain injury following ischemia-reperfusion (I/R). To determine whether TLR2 and TLR4 conferred cytoprotection in the heart, we subjected hearts of wild-type (WT) mice and mice deficient in TLR2 (TLR2D), TLR4 (TLR4D), and TIR domain-containing adapter protein (TIRAP-D) to ischemic preconditioning (IPC). Langendorff-perfused hearts were subjected to 30 min ischemia and 60 min reperfusion with or without IPC. IPC resulted in a significant increase (P < 0.05) in the percent recovery of left ventricular developed pressure (%LVDP) in WT mouse hearts (54.4 +/-2.7% of baseline), whereas there was no significant increase in %LVDP (P > 0.05) in TIRAP-D mouse hearts (43.8 +/-1.9%) after I/R injury. IPC also resulted in a significant (P < 0.05) decrease in I/R-induced creatine kinase release and Evans blue dye uptake in WT but not TIRAP-D hearts. Interestingly, IPC resulted in a significant (P < 0.05) increase in %LVDP in TLR4-deficient hearts (52.7 +/-3%) but not in TLR2D hearts (39.3 +/-1.5%). Pretreatment with a specific TLR2 ligand (Pam3CSK) protected WT hearts against I/R-induced left ventricular dysfunction. The loss of IPC-induced cardioprotection in TIRAP-D mouse hearts was accompanied by a decreased translocation of protein kinase C-epsilon and decreased phosphorylation of GSK-3beta. Taken together, these data suggest that the cardioprotective effect of IPC is mediated, at least in part, through a TLR2-TIRAP-dependent pathway, suggesting that the modulation of this pathway represents a viable target for reducing I/R injury."xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00306.2009"xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/author | "Thomas J.A."xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/author | "Mann D.L."xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/author | "Dong J.W."xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/author | "Vallejo J.G."xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/author | "Tzeng H.P."xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/pages | "H1079-87"xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/title | "Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/20061547 | http://purl.uniprot.org/core/volume | "298"xsd:string |
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