| http://purl.uniprot.org/citations/20062060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20062060 | http://www.w3.org/2000/01/rdf-schema#comment | "The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 x 10(-8). At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P < 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.517"xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Chung M.K."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Muller M."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Meitinger T."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Schlessinger D."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Rice K."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Rotter J.I."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Smith J.D."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Hofman A."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "van Duijn C.M."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Newton-Cheh C."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Muller-Myhsok B."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Wichmann H.E."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Benjamin E.J."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Boerwinkle E."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Chakravarti A."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Coresh J."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Kottgen A."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Levy D."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Rivadeneira F."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Witteman J.C."xsd:string |
| http://purl.uniprot.org/citations/20062060 | http://purl.uniprot.org/core/author | "Harris T.B."xsd:string |