| http://purl.uniprot.org/citations/20062519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20062519 | http://www.w3.org/2000/01/rdf-schema#comment | "WRN-1 is the Caenorhabditis elegans homolog of the human Werner syndrome protein, a RecQ helicase, mutations of which are associated with premature aging and increased genome instability. Relatively little is known as to how WRN-1 functions in DNA repair and DNA damage signaling. Here, we take advantage of the genetic and cytological approaches in C. elegans to dissect the epistatic relationship of WRN-1 in various DNA damage checkpoint pathways. We found that WRN-1 is required for CHK1 phosphorylation induced by DNA replication inhibition, but not by UV radiation. Furthermore, WRN-1 influences the RPA-1 focus formation, suggesting that WRN-1 functions in the same step or upstream of RPA-1 in the DNA replication checkpoint pathway. In response to ionizing radiation, RPA-1 focus formation and nuclear localization of ATM depend on WRN-1 and MRE-11. We conclude that C. elegans WRN-1 participates in the initial stages of checkpoint activation induced by DNA replication inhibition and ionizing radiation. These functions of WRN-1 in upstream DNA damage signaling are likely to be conserved, but might be cryptic in human systems due to functional redundancy."xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000801"xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/author | "Gartner A."xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/author | "Koo H.S."xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/author | "Ahn B."xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/author | "Hyun M."xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/pages | "e1000801"xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks."xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/20062519 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20062519 |
| http://purl.uniprot.org/citations/20062519 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20062519 |
| http://purl.uniprot.org/uniprot/Q9N3Q4#attribution-F24752E880EE963903ED419E4FA5D747 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20062519 |
| http://purl.uniprot.org/uniprot/#_Q19545-mappedCitation-20062519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20062519 |
| http://purl.uniprot.org/uniprot/#_Q19546-mappedCitation-20062519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20062519 |
| http://purl.uniprot.org/uniprot/#_Q9N3Q4-mappedCitation-20062519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20062519 |
| http://purl.uniprot.org/uniprot/Q9N3Q4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20062519 |
| http://purl.uniprot.org/uniprot/Q19545 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20062519 |
| http://purl.uniprot.org/uniprot/Q19546 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20062519 |