| http://purl.uniprot.org/citations/20062796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20062796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20062796 | http://www.w3.org/2000/01/rdf-schema#comment | "The physiological role of fungal galectins has remained elusive. Here, we show that feeding of a mushroom galectin, Coprinopsis cinerea CGL2, to Caenorhabditis elegans inhibited development and reproduction and ultimately resulted in killing of this nematode. The lack of toxicity of a carbohydrate-binding defective CGL2 variant and the resistance of a C. elegans mutant defective in GDP-fucose biosynthesis suggested that CGL2-mediated nematotoxicity depends on the interaction between the galectin and a fucose-containing glycoconjugate. A screen for CGL2-resistant worm mutants identified this glycoconjugate as a Galbeta1,4Fucalpha1,6 modification of C. elegans N-glycan cores. Analysis of N-glycan structures in wild type and CGL2-resistant nematodes confirmed this finding and allowed the identification of a novel putative glycosyltransferase required for the biosynthesis of this glycoepitope. The X-ray crystal structure of a complex between CGL2 and the Galbeta1,4Fucalpha1,6GlcNAc trisaccharide at 1.5 A resolution revealed the biophysical basis for this interaction. Our results suggest that fungal galectins play a role in the defense of fungi against predators by binding to specific glycoconjugates of these organisms."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1000717"xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1000717"xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Hengartner M.O."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Hengartner M.O."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Seeberger P.H."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Seeberger P.H."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Aebi M."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Aebi M."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Kuenzler M."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Kuenzler M."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Olieric V."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Olieric V."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Butschi A."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Butschi A."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Waelti M.A."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Waelti M.A."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Noebauer K."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Noebauer K."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Paschinger K."xsd:string |
| http://purl.uniprot.org/citations/20062796 | http://purl.uniprot.org/core/author | "Paschinger K."xsd:string |