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http://purl.uniprot.org/citations/20063526http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20063526http://www.w3.org/2000/01/rdf-schema#comment"

Background

Expression of myeloid or T cell lymphoid in precursor B cell acute lymphoblastic leukemia (pre-B cell ALL), which is referred to as aberrant expression, is quite a common phenomenon. CD66c is a myeloid marker which has aberrant expression in pre-B cell ALL, with strong correlation with non-random genetic changes (BCR/ABL rearrangement). Another leukemia associated marker (CD25) is frequently expressed in pre-B cell ALL. The frequency of CD25-expressing lymphoblasts has been found to be significantly higher in BCR/ABL-positive vs. BCR/ABL-negative patients.

Methods

In a cohort of 103 patients diagnosed with pre-B cell ALL or biphenotypic leukemia and studied for expression of CD66c and CD25 at presentation, we evaluated the frequency of expression of either or both in BCR/ABL positive cases.

Results

Surface CD66c was expressed by 70 cases (68%) and CD25 was expressed by 33 cases (32%) while both were expressed together on 29 cases (28%). BCR/ABL was positive in 18/103 patients. All BCR/ABL positive cases were positive for surface CD66c and CD25.

Conclusion

Positivity for both leukemia-associated antigens CD66c and CD25 in combination can predict the presence of BCR/ABL rearrangement in pre-B cell ALL. While this finding does not replace the detection of BCR/ABL abnormality by cytogenetic or molecular techniques, it does provide an early and handy tool for prediction and management of high-risk cases of pre-B cell ALL, especially in centers with limited laboratory facilities."xsd:string
http://purl.uniprot.org/citations/20063526http://purl.org/dc/terms/identifier"doi:10.1016/s1658-3876(08)50058-6"xsd:string
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/author"Owaidah T.M."xsd:string
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/author"Al Khayatt M.F."xsd:string
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/author"Elkum N.B."xsd:string
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/author"Rawas F.I."xsd:string
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/name"Hematol Oncol Stem Cell Ther"xsd:string
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/pages"34-37"xsd:string
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/title"Expression of CD66c and CD25 in acute lymphoblastic leukemia as a predictor of the presence of BCR/ABL rearrangement."xsd:string
http://purl.uniprot.org/citations/20063526http://purl.uniprot.org/core/volume"1"xsd:string
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