| http://purl.uniprot.org/citations/20064468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20064468 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the parkin gene are responsible for a common inherited form of Parkinson's disease (PD). Parkin is a RING-type E3 ubiquitin ligase with an N-terminal ubiquitin-like domain (Ubl). We report here that the parkin Ubl binds SH3 domains from endocytic BAR proteins such as endophilin-A with an affinity comparable to proline-rich domains (PRDs) from well-established SH3 partners. The NMR structure of the Ubl-SH3 complex identifies the PaRK extension, a unique C-terminal motif in the parkin Ubl required for SH3 binding and for parkin-mediated ubiquitination of endophilin-A in vitro. In nerve terminals, conditions that promote phosphorylation enhance the interaction between parkin and endophilin-A and increase the levels of ubiquitinated proteins within PRD-associated synaptic protein complexes in wild-type but not parkin knockout brain. The findings identify a pathway for the recruitment of synaptic substrates to parkin with the potential to explain the defects in synaptic transmission observed in recessive forms of PD."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.11.021"xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/author | "McPherson P.S."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/author | "Gehring K."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/author | "Kozlov G."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/author | "Trempe J.F."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/author | "Fon E.A."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/author | "Grenier K."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/author | "Chen C.X."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/author | "Camacho E.M."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/pages | "1034-1047"xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/title | "SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/20064468 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20064468 |
| http://purl.uniprot.org/citations/20064468 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20064468 |
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