| http://purl.uniprot.org/citations/20065157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20065157 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently found that endogenous (free fatty acids) and pharmacological (thiazolidinediones) agonists of nuclear receptor Peroxisome proliferator-activated receptor (PPAR)gamma stimulate renin transcription. In addition, the renin gene was identified as a direct target of PPARgamma. The mouse renin gene is regulated by PPARgamma through a distal enhancer direct repeat closely related to consensus PPAR response element (PPRE). In vitro studies demonstrated that PPARgamma knockdown stimulated PPRE-driven transcription. These data predicted that deficiency of PPARgamma would upregulate mouse renin expression. Consistent with these observations knockdown of PPARgamma increased the transcription of a reporter gene driven by the mouse renin PPRE-like motif in vitro. To study the impact of PPARgamma on renin production in vivo, we used a cre/lox system to generate double-transgenic mice with disrupted PPARgamma locus in renin-producing juxtaglomerular (JG) cells of the kidney (RC-PPARgamma(fl/fl) mice). We provide evidence that PPARgamma expression was effectively reduced in JG cells of RC-PPARgamma(fl/fl) mice. Fluorescent immunohistochemistry showed stronger renin signal in RC-PPARgamma(fl/fl) than in littermate control RC-PPARgamma(wt/wt) mice. Renin mRNA levels and plasma renin concentration in RC-PPARgamma(fl/fl) mice were almost 2-fold higher than in littermate controls. Arterial blood pressure and pressure control of renal vascular resistance, which play decisive roles in the regulation of renin production were indistinguishable between RC-PPARgamma(wt/wt) and RC-PPARgamma(fl/fl) mice. These data demonstrate that the JG-specific PPARgamma deficiency results in increased mouse renin expression in vivo thus corroborating earlier in vitro results. PPARgamma appears to be a relevant transcription factor for the control of renin gene in JG cells."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.109.138800"xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Gomez R.A."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Schreiber A."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Madsen K."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Sigmund C.D."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Friis U.G."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Desch M."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Sequeira Lopez M.L."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Schweda F."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Todorov V.T."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/author | "Weatherford E.T."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/pages | "660-666"xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/title | "Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells."xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/20065157 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20065157 |
| http://purl.uniprot.org/citations/20065157 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20065157 |
| http://purl.uniprot.org/uniprot/#_D0EPX6-mappedCitation-20065157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065157 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV67-mappedCitation-20065157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065157 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVF8-mappedCitation-20065157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065157 |
| http://purl.uniprot.org/uniprot/#_A0N0C8-mappedCitation-20065157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065157 |
| http://purl.uniprot.org/uniprot/#_A0N0D0-mappedCitation-20065157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065157 |