| http://purl.uniprot.org/citations/20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20065289 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucocorticoids potently attenuate the production of inflammatory mediators by macrophages, a primary effector of innate immunity. Activation of different macrophage Toll-like receptors (TLRs) by their respective ligands presents a powerful system by which to evaluate stimulus-dependent glucocorticoid effects in the same cell type. Here, we test the hypothesis that glucocorticoids, acting through the glucocorticoid receptor, modulate macrophage activation preferentially depending upon the TLR-selective ligand and TLR adapters. We established that 2 adapters, Trif, MyD88, or both, determine the ability of glucocorticoids to suppress inhibitor of kappaB (IkappaB) degradation or Janus kinase (JNK) activation. Moreover, the sensitivity of transforming growth factor beta-activated kinase 1 (TAK1) activation to glucocorticoids determines these effects. These findings identify TAK1 as a novel target for glucocorticoids that integrates their anti-inflammatory action in innate immunity signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-06-224782"xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/author | "Kelley C."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/author | "Bhattacharyya S."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/author | "Muglia L.J."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/author | "Vogt S.K."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/author | "Schreiber R.D."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/author | "Ratajczak C.K."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/pages | "1921-1931"xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/title | "TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in Toll-like receptor-stimulated macrophages."xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/20065289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20065289 |
| http://purl.uniprot.org/citations/20065289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20065289 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065289 |
| http://purl.uniprot.org/uniprot/#_D3Z280-mappedCitation-20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065289 |
| http://purl.uniprot.org/uniprot/#_A2AP92-mappedCitation-20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065289 |
| http://purl.uniprot.org/uniprot/#_A2AP93-mappedCitation-20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065289 |
| http://purl.uniprot.org/uniprot/#_A0A385HBV1-mappedCitation-20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065289 |
| http://purl.uniprot.org/uniprot/#_A0A494B9W1-mappedCitation-20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065289 |
| http://purl.uniprot.org/uniprot/#_E9Q310-mappedCitation-20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065289 |
| http://purl.uniprot.org/uniprot/#_E9Q8A6-mappedCitation-20065289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20065289 |