| http://purl.uniprot.org/citations/20070859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20070859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20070859 | http://www.w3.org/2000/01/rdf-schema#comment | "Organisms have evolved diverse means to protect themselves from oxidative stress. To better understand the molecular mechanisms involved in oxidative stress resistance, we screened fission yeast mutants sensitive to paraquat, a reagent acting on the mitochondria to generate reactive oxygen species. Among the mutants we isolated, we focused on a mutant defective in the vps1(+) (vacuolar protein sorting 1) gene that encodes a dynamin-related protein family member. vps1Δ exhibited aberrant mitochondrial and vacuolar morphology on treatment with paraquat. vps1Δ was sensitive to osmotic stress, high concentrations of Ca(2+) and Fe(2+). Interestingly, the deletion of atg8(+), a gene essential for the autophagy pathway, exhibited strong genetic interactions with vps1Δ. The vps1Δatg8Δ double mutant was additively sensitive to oxidative stress, osmotic stress and Ca(2+). The deletion of vps1(+) rescued the bizarre vacuolar morphology shown by atg8Δ. Such genetic interactions were not observed with other atg mutants. Furthermore, the atg8-G116A mutant did not show abnormal vacuolar morphology while being sensitive to nitrogen starvation, an autophagy-related phenotype. Taken together, we conclude that atg8(+) regulates vacuolar functions independently of its role in autophagy. We propose that Vps1 and Atg8 cooperatively participate in vacuolar function, thereby contributing to oxidative stress resistance."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2009.01376.x"xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2009.01376.x"xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/author | "Mikawa T."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/author | "Mikawa T."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/author | "Kanoh J."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/author | "Kanoh J."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/author | "Ishikawa F."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/author | "Ishikawa F."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/pages | "229-242"xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/pages | "229-242"xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/title | "Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/title | "Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance."xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/20070859 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20070859 |
| http://purl.uniprot.org/citations/20070859 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20070859 |
| http://purl.uniprot.org/citations/20070859 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20070859 |
| http://purl.uniprot.org/citations/20070859 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20070859 |