| http://purl.uniprot.org/citations/20075068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20075068 | http://www.w3.org/2000/01/rdf-schema#comment | "Stefin B (cystatin B) is an endogenous inhibitor of cysteine proteinases localized in the nucleus and the cytosol. Loss-of-function mutations in the stefin B gene (CSTB) gene were reported in patients with Unverricht-Lundborg disease (EPM1). We have identified an interaction between stefin B and nucleosomes, specifically with histones H2A.Z, H2B, and H3. In synchronized T98G cells, stefin B co-immunoprecipitated with histone H3, predominantly in the G(1) phase of the cell cycle. Stefin B-deficient mouse embryonic fibroblasts entered S phase earlier than wild type mouse embryonic fibroblasts. In contrast, increased expression of stefin B in the nucleus delayed cell cycle progression in T98G cells. The delay in cell cycle progression was associated with the inhibition of cathepsin L in the nucleus, as judged from the decreased cleavage of the CUX1 transcription factor. In vitro, inhibition of cathepsin L by stefin B was potentiated in the presence of histones, whereas histones alone did not affect the cathepsin L activity. Interaction of stefin B with the Met-75 truncated form of cathepsin L in the nucleus was confirmed by fluorescence resonance energy transfer experiments in the living cells. Stefin B could thus play an important role in regulating the proteolytic activity of cathepsin L in the nucleus, protecting substrates such as transcription factors from its proteolytic processing."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.034793"xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Maher K."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Krizaj I."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Turk B."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Bencina M."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Renko M."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Nepveu A."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Zerovnik E."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Repnik U."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Ceru S."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Kopitar-Jerala N."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/author | "Konjar S."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/pages | "10078-10086"xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/title | "Stefin B interacts with histones and cathepsin L in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20075068 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20075068 |
| http://purl.uniprot.org/citations/20075068 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20075068 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VJC1-mappedCitation-20075068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20075068 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VNM3-mappedCitation-20075068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20075068 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VNQ4-mappedCitation-20075068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20075068 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VP49-mappedCitation-20075068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20075068 |