| http://purl.uniprot.org/citations/20075254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20075254 | http://www.w3.org/2000/01/rdf-schema#comment | "Integrins mediate cell adhesion to the extracellular matrix and transmit signals within the cell that stimulate cell spreading, retraction, migration, and proliferation. The mechanism of integrin outside-in signaling has been unclear. We found that the heterotrimeric guanine nucleotide-binding protein (G protein) Galpha13 directly bound to the integrin beta3 cytoplasmic domain and that Galpha13-integrin interaction was promoted by ligand binding to the integrin alphaIIbbeta3 and by guanosine triphosphate (GTP) loading of Galpha13. Interference of Galpha13 expression or a myristoylated fragment of Galpha13 that inhibited interaction of alphaIIbbeta3 with Galpha13 diminished activation of protein kinase c-Src and stimulated the small guanosine triphosphatase RhoA, consequently inhibiting cell spreading and accelerating cell retraction. We conclude that integrins are noncanonical Galpha13-coupled receptors that provide a mechanism for dynamic regulation of RhoA."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1174779"xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/author | "Chow C."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/author | "Gong H."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/author | "Lam S.C."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/author | "Kozasa T."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/author | "Voyno-Yasenetskaya T.A."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/author | "Flevaris P."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/pages | "340-343"xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/title | "G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling."xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://purl.uniprot.org/core/volume | "327"xsd:string |
| http://purl.uniprot.org/citations/20075254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20075254 |
| http://purl.uniprot.org/citations/20075254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20075254 |
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| http://purl.uniprot.org/uniprot/#_A0A6B9NYH9-mappedCitation-20075254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20075254 |
| http://purl.uniprot.org/uniprot/#_B2RPR7-mappedCitation-20075254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20075254 |
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| http://purl.uniprot.org/uniprot/#_B4DLU2-mappedCitation-20075254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20075254 |
| http://purl.uniprot.org/uniprot/#_B7Z8B0-mappedCitation-20075254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20075254 |