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http://purl.uniprot.org/citations/20078932http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20078932http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To explore the influences of the restoration of neural adhesion molecule NECL1 on the morphology, migration, and invasion of NECL1-deficient glioma cell lines.

Methods

Scratch and Transwell assays were used to observe the cell migration and invasion, the activities of extracellular metalloproteinases were measured, and the cell morphology was observed. Astrocytes marker glial fibrillary acidic protein was detected by Western blot after the restoration of NECL1 in glioma U251 cell line.

Results

In NECL1-deficient U251 glioma cell lines, migration and invasion were inhibited. The U251 cells was differentiated potentially to astrocytes, and glial fibrillary acidic protein was up-regulated after the restoration of the NECL1 expression.

Conclusion

As a potential tumor repressor, the neural adhesion molecule NECL1 can inhibit the migration and invasion of glioma cell and induces its differentiation."xsd:string
http://purl.uniprot.org/citations/20078932http://purl.org/dc/terms/identifier"doi:10.3881/j.issn.1000-503x.2009.06.003"xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/author"Chen T."xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/author"Gao J."xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/author"Yuan J.G."xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/author"Yin B."xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/author"Peng X.Z."xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/name"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/pages"669-673"xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/title"[Neural adhesion molecule NECL1 inhibits migration, invasion, and potentially induces differentiation of glioma cell]."xsd:string
http://purl.uniprot.org/citations/20078932http://purl.uniprot.org/core/volume"31"xsd:string
http://purl.uniprot.org/citations/20078932http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20078932
http://purl.uniprot.org/citations/20078932http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20078932
http://purl.uniprot.org/uniprot/#_A0A0C4DG09-mappedCitation-20078932http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20078932
http://purl.uniprot.org/uniprot/#_Q8N126-mappedCitation-20078932http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20078932
http://purl.uniprot.org/uniprot/Q8N126http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20078932
http://purl.uniprot.org/uniprot/A0A0C4DG09http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20078932