| http://purl.uniprot.org/citations/20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20079163 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundKCNJ11, ABCC8, PPARG, and HNF4A have been found to be associated with type 2 diabetes in populations with different genetic backgrounds. The aim of this study was to test, in a Chinese Han population from Beijing, whether the genetic variants in these four genes were associated with genetic predisposition to type 2 diabetes.MethodsWe studied the association of four representative SNPs in KCNJ11, ABCC8, PPARG, and HNF4A by genotyping them using ABI SNaPshot Multiplex System in 400 unrelated type 2 diabetic patients and 400 unrelated normoglycaemic subjects.Resultsrs5219 (E23K) in KCNJ11 was associated with genetic susceptibility to type 2 diabetes (OR = 1.400 with 95% CI 1.117 1.755, P = 0.004 under an additive model, OR = 1.652 with 95% CI 1.086 2.513, P = 0.019 under a recessive model, and OR = 1.521 with 95% CI 1.089 2.123, P = 0.014 under a dominant model) after adjusting for sex and body mass index (BMI). We did not find evidence of association for ABCC8 rs1799854, PPARG rs1801282 (Pro12Ala) and HNF4A rs2144908. Genotype-phenotype correlation analysis revealed that rs1799854 in ABCC8 was associated with 2-hour postprandial insulin secretion (P = 0.005) after adjusting for sex, age and BMI. Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P = 0.004 under an additive model for rs2144908; and P = 0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala.ConclusionsOur study replicated the association of rs5219 in KCNJ11 with type 2 diabetes in Chinese Han population in Beijing. And we also observed that ABCC8 as well as the interaction between PPARG and HNF4A may contribute to post-challenge insulin secretion."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/author | "Ren Q."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/author | "Zhou X.H."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/author | "Zhang X.Y."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/author | "Han L.C."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/author | "Luo Y.Y."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/author | "Han X.Y."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/author | "Ji L.N."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/name | "Chin Med J (Engl)"xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/pages | "2477-2482"xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/title | "Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population."xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/20079163 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20079163 |
| http://purl.uniprot.org/citations/20079163 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20079163 |
| http://purl.uniprot.org/uniprot/#_A0A220SZY8-mappedCitation-20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20079163 |
| http://purl.uniprot.org/uniprot/#_A0A220SZZ5-mappedCitation-20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20079163 |
| http://purl.uniprot.org/uniprot/#_E9PFV2-mappedCitation-20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20079163 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4K5-mappedCitation-20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20079163 |
| http://purl.uniprot.org/uniprot/#_A0A3P3ZKM0-mappedCitation-20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20079163 |
| http://purl.uniprot.org/uniprot/#_A0A494C1F9-mappedCitation-20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20079163 |
| http://purl.uniprot.org/uniprot/#_A0A804HHV7-mappedCitation-20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20079163 |
| http://purl.uniprot.org/uniprot/#_B6ZGS2-mappedCitation-20079163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20079163 |