| http://purl.uniprot.org/citations/20079431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20079431 | http://www.w3.org/2000/01/rdf-schema#comment | "Bcr-Abl is the transforming principle underlying chronic myelogenous leukaemia (CML). Here, we use a functional interaction proteomics approach to map pathways by which Bcr-Abl regulates defined cellular processes. The results show that Bcr-Abl regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76/Nck1 adaptor protein pathway. The binding of GADS to Bcr-Abl requires Bcr-Abl tyrosine kinase activity and is sensitive to the Bcr-Abl inhibitor imatinib, while the GADS/Slp-76 and Slp-76/Nck interactions are tyrosine phosphorylation independent. All three adaptor proteins co-localize with cortical actin in membrane blebs. Downregulation of each adaptor protein disrupts the actin cytoskeleton and membrane blebbing in a similar fashion and similar to imatinib. These findings highlight the importance of protein interaction dependent adaptor protein pathways in oncogenic kinase signaling."xsd:string |
| http://purl.uniprot.org/citations/20079431 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2009.12.012"xsd:string |
| http://purl.uniprot.org/citations/20079431 | http://purl.uniprot.org/core/author | "Kolch W."xsd:string |
| http://purl.uniprot.org/citations/20079431 | http://purl.uniprot.org/core/author | "Preisinger C."xsd:string |
| http://purl.uniprot.org/citations/20079431 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20079431 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/20079431 | http://purl.uniprot.org/core/pages | "848-856"xsd:string |
| http://purl.uniprot.org/citations/20079431 | http://purl.uniprot.org/core/title | "The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway."xsd:string |
| http://purl.uniprot.org/citations/20079431 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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