| http://purl.uniprot.org/citations/20079709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20079709 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study addresses the insulin sensitivity in mice deficient in LXRbeta (LXRbeta(-/-)) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp. Wt and LXRbeta(-/-) mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps. We show that LXRbeta(-/-) mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet. Moreover we also observed reduced hepatic inflammation in LXRbeta(-/-) mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXRbeta(-/-) mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26weeks."xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.01.042"xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/author | "Nebb H.I."xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/author | "Voshol P.J."xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/author | "Holm S."xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/pages | "436-441"xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/title | "LXRbeta deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp."xsd:string |
| http://purl.uniprot.org/citations/20079709 | http://purl.uniprot.org/core/volume | "392"xsd:string |
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