| http://purl.uniprot.org/citations/20080577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20080577 | http://www.w3.org/2000/01/rdf-schema#comment | "The human histone H3 variant, CENP-A, replaces the conventional histone H3 in centromeric chromatin and, together with centromere-specific DNA-binding factors, directs the assembly of the kinetochore. We purified the prenucelosomal e-CENP-A complex. We found that HJURP, a member of the complex, was required for cell cycle specific targeting of CENP-A to centromeres. HJURP facilitated efficient deposition of CENP-A/H4 tetramers to naked DNA in vitro. Bacterially expressed HJURP binds at a stoichiometric ratio to the CENP-A/H4 tetramer but not to the H3/H4 tetramer. The binding occurred through a conserved HJURP short N-terminal domain, termed CBD. The novel characteristic identified in vertebrates that we named TLTY box of CBD, was essential for formation of the HJURP-CENP-A/H4 complex. Our data identified HJURP as a vertebrate CENP-A chaperone and dissected its mode of interactions with CENP-A."xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0913709107"xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/author | "Hamiche A."xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/author | "Dimitrov S."xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/author | "Ouararhni K."xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/author | "Shuaib M."xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/pages | "1349-1354"xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/title | "HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres."xsd:string |
| http://purl.uniprot.org/citations/20080577 | http://purl.uniprot.org/core/volume | "107"xsd:string |
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