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http://purl.uniprot.org/citations/20087352http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20087352http://www.w3.org/2000/01/rdf-schema#comment"

Background

Altered DNA repair may be associated with aggressive tumour biology and impact upon response to chemotherapy and radiotherapy. We investigated whether expression of human AP endonuclease (APE1), a key multifunctional protein involved in DNA BER, would impact on clinicopathological outcomes in ovarian, gastro-oesophageal, and pancreatico-biliary cancer.

Methods

Formalin-fixed human ovarian, gastro-oesophageal, and pancreatico-biliary cancers were constructed into TMAs. Expression of APE1 was analysed by IHC and correlated to clinicopathological variables.

Results

In ovarian cancer, nuclear APE1 expression was seen in 71.9% (97 out of 135) of tumours and correlated with tumour type (P=0.006), optimal debulking (P=0.009), and overall survival (P=0.05). In gastro-oesophageal cancers previously exposed to neoadjuvant chemotherapy, 34.8% (16 out of 46) of tumours were positive in the nucleus and this correlated with shorter overall survival (P=0.005), whereas cytoplasmic localisation correlated with tumour dedifferentiation (P=0.034). In pancreatico-biliary cancer, nuclear staining was seen in 44% (32 out of 72) of tumours. Absence of cytoplasmic staining was associated with perineural invasion (P=0.007), vascular invasion (P=0.05), and poorly differentiated tumours (P=0.068). A trend was noticed with advanced stage (P=0.077).

Conclusions

Positive clinicopathological correlations of APE1 expression suggest that APE1 is a potential drug target in ovarian, gastro-oesophageal, and pancreatico-biliary cancers."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.org/dc/terms/identifier"doi:10.1038/sj.bjc.6605541"xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Chan S."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Mohammed M."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Madhusudan S."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Al-Attar A."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Shehata M."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Lobo D.N."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Zaitoun A.M."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Abbotts R."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Fareed K.R."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Gossage L."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/author"Soomro I."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/name"Br J Cancer"xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/pages"704-709"xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/title"Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers."xsd:string
http://purl.uniprot.org/citations/20087352http://purl.uniprot.org/core/volume"102"xsd:string
http://purl.uniprot.org/citations/20087352http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20087352
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http://purl.uniprot.org/uniprot/#_P27695-mappedCitation-20087352http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20087352
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