| http://purl.uniprot.org/citations/20087941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20087941 | http://www.w3.org/2000/01/rdf-schema#comment | "Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a complication that affects up to 5% of HTLV-1-infected individuals. Several host genetic and viral factors have been associated with the risk of HAM/TSP. The aim of this study was to evaluate the performance of a prognostic model for HAM/TSP developed in Japan in a Peruvian population of 71 HAM/TSP patients and 94 asymptomatic carriers (ACs). This model included age, proviral load (PVL), the presence of HLA-A*02 and HLA-Cw*08 alleles, SDF-1 +801, and TNF-alpha -863 polymorphisms, and viral subgroup. We describe frequencies for the four host genetic markers and demonstrate the presence of the HTLV-1 tax B subgroup in Peru. Using cross-validation, we show that the predictive ability of the prognostic model, as characterized by the area under the receiver-operating characteristic curve (AUC), does not differ from a model containing PVL only (both AUC = 0.74). We found some suggestive evidence of a protective effect of the HLA-A*02 allele but failed to replicate the associations with the other three genetic markers and with viral subgroup. A logistic model containing PVL, age, gender, and HLA-A*02 provided the best predictive ability in the Peruvian cohort (AUC = 0.79). J. Med. Virol. 82:460-466, 2010. (c) 2010 Wiley-Liss, Inc."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.org/dc/terms/identifier | "doi:10.1002/jmv.21675"xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Lopez G."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Gonzalez E."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Clark D."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Vanham G."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Van Laer L."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Van Camp G."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Huyghe J.R."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Gotuzzo E."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Adaui V."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Talledo M."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Best I."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/author | "Verdonck K."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/name | "J Med Virol"xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/pages | "460-466"xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/title | "Evaluation of host genetic and viral factors as surrogate markers for HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian HTLV-1-infected patients."xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/20087941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20087941 |
| http://purl.uniprot.org/citations/20087941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20087941 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-20087941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20087941 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-20087941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20087941 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-20087941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20087941 |