| http://purl.uniprot.org/citations/20089716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20089716 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 6 (IL6) is a pleiotropic cytokine that not only affects the immune system, but also plays an active role in many physiological events in various organs. Notably, 35% of systemic IL6 originates from adipose tissues under noninflammatory conditions. Here, we describe a previously unknown function of melanocortins in regulating Il6 gene expression and production in 3T3-L1 adipocytes through membrane receptors which are called melanocortin receptors (MCRs). Of the five MCRs that have been cloned, MC2R and MC5R are expressed during adipocyte differentiation. alpha-Melanocyte-stimulating hormone (alpha-MSH) or ACTH treatment of 3T3-L1 adipocytes induces Il6 gene expression and production in a time- and concentration-dependent manner via various signaling pathways including the protein kinase A, p38 mitogen-activated protein kinase, cJun N-terminal kinase, and IkappaB kinase pathways. Specific inhibition of MC2R and MC5R expression with short interfering Mc2r and Mc5r RNAs significantly attenuated the alpha-MSH-induced increase of intracellular cAMP and both the level of Il6 mRNA and secretion of IL6 in 3T3-L1 adipocytes. Finally, when injected into mouse tail vein, alpha-MSH dramatically increased the Il6 transcript levels in epididymal fat pads. These results suggest that alpha-MSH in addition to ACTH may function as a regulator of inflammation by regulating cytokine production."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.org/dc/terms/identifier | "doi:10.1677/jme-09-0161"xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Kim W."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Yoon J.H."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Kwon E.J."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Kim K.T."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Ryu S.H."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Suh P.G."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Kwak D."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Jun D.J."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Na K.Y."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/author | "Yea K."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/name | "J Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/pages | "225-236"xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/title | "Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes."xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/20089716 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20089716 |
| http://purl.uniprot.org/citations/20089716 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20089716 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-20089716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20089716 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-20089716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20089716 |
| http://purl.uniprot.org/uniprot/#_A2RTD1-mappedCitation-20089716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20089716 |