| http://purl.uniprot.org/citations/20089890 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20089890 | http://www.w3.org/2000/01/rdf-schema#comment | "Endosomal sorting mechanisms mediated by AP-3 and BLOC-1 are perturbed in Hermansky-Pudlak Syndrome, a human genetic condition characterized by albinism and prolonged bleeding (OMIM #203300). Additionally, mouse models defective in either one of these complexes possess defective synaptic vesicle biogenesis (Newell-Litwa et al., 2009). These synaptic vesicle phenotypes were presumed uniform throughout the brain. However, here we report that AP-3 and BLOC-1 differentially regulate the composition of presynaptic terminals in the striatum and dentate gyrus of the hippocampus. Quantitative immunoelectron microscopy demonstrated that the majority of AP-3 immunoreactivity in both wild-type striatum and hippocampus localizes to presynaptic axonal compartments, where it regulates synaptic vesicle size. In the striatum, loss of AP-3 (Ap3d(mh/mh)) resulted in decreased synaptic vesicle size. In contrast, loss of AP-3 in the dentate gyrus increased synaptic vesicle size, thus suggesting anatomically specific AP-3-regulatory mechanisms. Loss-of-function alleles of BLOC-1, Pldn(pa/pa), and Muted(mu/mu) revealed that this complex acts as a brain-region-specific regulator of AP-3. In fact, BLOC-1 deficiencies selectively reduced AP-3 and AP-3 cargo immunoreactivity in presynaptic compartments within the dentate gyrus both at the light and/or electron microscopy level. However, the striatum did not exhibit these BLOC-1-null phenotypes. Our results demonstrate that distinct brain regions differentially regulate AP-3-dependent synaptic vesicle biogenesis. We propose that anatomically restricted mechanisms within the brain diversify the biogenesis and composition of synaptic vesicles."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3400-09.2010"xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/author | "Faundez V."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/author | "Smith Y."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/author | "Pare J.F."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/author | "Jenkins S."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/author | "Chintala S."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/author | "Newell-Litwa K."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/author | "McGaha L."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/pages | "820-831"xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/title | "Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus."xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/20089890 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20089890 |
| http://purl.uniprot.org/citations/20089890 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20089890 |
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