| http://purl.uniprot.org/citations/20096780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20096780 | http://www.w3.org/2000/01/rdf-schema#comment | "Here, we demonstrate that ADAMTS9, a highly conserved versican-degrading protease, is required for correct cardiovascular development and adult homeostasis. Analysis of Adamts9(+/LacZ) adult mice revealed anomalies in the aortic wall, valvulosinus and valve leaflets. Abnormal myocardial projections and 'spongy' myocardium consistent with non-compaction of the left ventricle were also found in Adamts9(+/LacZ) mice. During development, Adamts9 was expressed in derivatives of the Secondary Heart Field, vascular smooth muscle cells in the arterial wall, mesenchymal cells of the valves, and non-myocardial cells of the ventricles, but expression also continued in the adult heart and ascending aorta. Thus, the adult cardiovascular anomalies found in Adamts9(+/LacZ) hearts could result from subtle developmental alterations in extracellular matrix remodeling or defects in adult homeostasis. The valvular and aortic anomalies of Adamts9(+/LacZ) hearts were associated with accumulation of versican and a decrease in cleaved versican relative to WT littermates. These data suggest a potentially important role for ADAMTS9 cleavage of versican, or other, as yet undefined substrates in development and allostasis of cardiovascular extracellular matrix. In addition, these studies identify ADAMTS9 as a potential candidate gene for congenital cardiac anomalies. Mouse models of ADAMTS9 deficiency may be useful to study myxomatous valve degeneration."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2010.01.005"xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Menick D.R."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Nelson C.M."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Argraves W.S."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Apte S.S."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Wessels A."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Kern C.B."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Dixon L.J."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Alston E."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "Geeting D."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/author | "McGarity J."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/name | "Matrix Biol"xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/pages | "304-316"xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/title | "Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies."xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20096780 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20096780 |
| http://purl.uniprot.org/citations/20096780 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20096780 |
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| http://purl.uniprot.org/uniprot/#_E9Q5P9-mappedCitation-20096780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20096780 |