| http://purl.uniprot.org/citations/20097574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20097574 | http://www.w3.org/2000/01/rdf-schema#comment | "CKbeta8/CCL23 is a CC chemokine and alternative splicing of the CKbeta8 gene produces two mRNAs that encode CKbeta8 and its isoform CKbeta8-1. Chemokines play a critical role in leukocyte trafficking and development of inflammation and chemokines are also known to be involved in cell proliferation. To investigate participation of CKbeta8 and CKbeta8-1 in cell proliferation, we examined the effects of CKbeta8 and CKbeta8-1 in the cell cycle. Both CKbeta8 and CKbeta8-1 induced cell-cycle progression. We next investigated whether MAPKs are involved in CKbeta8- and CKbeta8-1-induced cell proliferation. CKbeta8- and CKbeta8-1-stimulated cells showed phosphorylation of ERK1/2 and an inhibitor study indicated that CKbeta8- and CKbeta8-1-induced activation of ERK1/2 is mediated by the G(i)/G(o) protein, PLC, and PKCdelta. CKbeta8 and CKbeta8-1 regulated expression of the cell cycle regulators cyclin D(3) and cyclin B(1,) and the immediate early response gene products c-Myc and Egr-1. These results indicate that both CKbeta8 and CKbeta8-1 are involved in cell proliferation by modulating the cell cycle regulators."xsd:string |
| http://purl.uniprot.org/citations/20097574 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2009.12.010"xsd:string |
| http://purl.uniprot.org/citations/20097574 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/20097574 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/20097574 | http://purl.uniprot.org/core/author | "Ko J."xsd:string |
| http://purl.uniprot.org/citations/20097574 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20097574 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/20097574 | http://purl.uniprot.org/core/pages | "42-49"xsd:string |
| http://purl.uniprot.org/citations/20097574 | http://purl.uniprot.org/core/title | "CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-cycle progression."xsd:string |
| http://purl.uniprot.org/citations/20097574 | http://purl.uniprot.org/core/volume | "50"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B4DFV1-mappedCitation-20097574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097574 |
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| http://purl.uniprot.org/uniprot/#_B4DRB9-mappedCitation-20097574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097574 |
| http://purl.uniprot.org/uniprot/#_B3KP89-mappedCitation-20097574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097574 |
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| http://purl.uniprot.org/uniprot/#_H1UBN2-mappedCitation-20097574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097574 |