| http://purl.uniprot.org/citations/20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20097880 | http://www.w3.org/2000/01/rdf-schema#comment | "P-selectin expression has been shown in Helicobacter pylori-infected persons, an infection that has been clinically associated with platelet-related diseases, such as idiopathic thrombocytopenic purpura. However, the role of P-selectin expression during H pylori infection remains unclear. In this study, we hypothesized that P-selectin expression was associated with platelet aggregation during H pylori infection. Using flow cytometry, we examined the levels of adhesion between H pylori and platelets as well as the levels of P-selectin expression and platelet phosphatidylserine (PS) expression during H pylori infection. Significantly high levels of adhesion between pro-aggregatory bacteria and platelets were observed. We identified that H pylori IgG is required for bacteria to induce P-selectin expression and that a significant release of P-selectin is essential for H pylori to induce aggregation. In addition, cellular apoptotic signs, such as membrane blebbing, were observed in platelet aggregates. PS expression was also detected in platelets during infection with both pro-aggrogatory and nonaggregatory strains of H pylori. These results suggest that the decrease in platelet counts seen during H pylori infection is the result of P-selection-dependent platelet aggregation and PS expression induced by the bacteria."xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-09-241166"xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/author | "Tsai S."xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/author | "Liu T.C."xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/author | "Wu J.Y."xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/author | "Wu D.C."xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/author | "Yeh J.J."xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/pages | "4247-4253"xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/title | "P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection."xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/20097880 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20097880 |
| http://purl.uniprot.org/citations/20097880 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20097880 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z509-mappedCitation-20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097880 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4F5-mappedCitation-20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097880 |
| http://purl.uniprot.org/uniprot/#_B2R785-mappedCitation-20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097880 |
| http://purl.uniprot.org/uniprot/#_P16109-mappedCitation-20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097880 |
| http://purl.uniprot.org/uniprot/#_Q6ULR6-mappedCitation-20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097880 |
| http://purl.uniprot.org/uniprot/#_Q5R341-mappedCitation-20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097880 |
| http://purl.uniprot.org/uniprot/#_Q6NUL9-mappedCitation-20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097880 |
| http://purl.uniprot.org/uniprot/#_Q8N1E9-mappedCitation-20097880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20097880 |
| http://purl.uniprot.org/uniprot/Q6NUL9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20097880 |