| http://purl.uniprot.org/citations/20099279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20099279 | http://www.w3.org/2000/01/rdf-schema#comment | "We report that melanoma cell lines expressing the interleukin-1 receptor exhibit 4-to 10-fold lower levels of mRNA of microphthalmia-associated transcription factor (MITF-M) when treated with interleukin-1beta. This effect is NF-kappaB and JNK-dependent. MITF-M regulates the expression of melanocyte differentiation genes such as MLANA, tyrosinase and gp100, which encode antigens recognized on melanoma cells by autologous cytolytic T lymphocytes. Accordingly, treating some melanoma cells with IL-1beta reduced by 40-100% their ability to activate such antimelanoma cytolytic T lymphocytes. Finally, we observed large amounts of biologically active IL-1alpha or IL-1beta secreted by two melanoma cell lines that did not express MITF-M, suggesting an autocrine MITF-M downregulation. We estimate that approximately 13% of melanoma cell lines are MITF-M-negative and secrete IL-1 cytokines. These results indicate that the repression of melanocyte-differentiation genes by IL-1 produced by stromal cells or by tumor cells themselves may represent an additional mechanism of melanoma immune escape."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.25182"xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "Brasseur F."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "Coulie P."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "van der Bruggen P."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "De Plaen E."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "van Baren N."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "Kholmanskikh O."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "Ottaviani S."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "Arts N."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/author | "Vanacker J."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/pages | "1625-1636"xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/title | "Interleukins 1alpha and 1beta secreted by some melanoma cell lines strongly reduce expression of MITF-M and melanocyte differentiation antigens."xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/20099279 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20099279 |
| http://purl.uniprot.org/citations/20099279 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20099279 |
| http://purl.uniprot.org/uniprot/#_A0A087WXU1-mappedCitation-20099279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20099279 |
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| http://purl.uniprot.org/uniprot/#_A0A8F9W6H4-mappedCitation-20099279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20099279 |
| http://purl.uniprot.org/uniprot/#_A0A0A7NWS7-mappedCitation-20099279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20099279 |
| http://purl.uniprot.org/uniprot/#_B4DNC7-mappedCitation-20099279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20099279 |
| http://purl.uniprot.org/uniprot/#_A8K5K3-mappedCitation-20099279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20099279 |