| http://purl.uniprot.org/citations/20100282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20100282 | http://www.w3.org/2000/01/rdf-schema#comment | "The neuronally expressed G beta(5) subunit is the most structurally divergent among heterotrimeric G beta isoforms and unique in its ability to heterodimerize with the R7 subfamily of regulator of G protein signaling (RGS) proteins. The complex between G beta(5) and R7-type RGS proteins targets the cell nucleus by an unknown mechanism. Although the nuclear targeting of the G beta(5)/R7-RGS complex is proposed to involve the binding of R7-binding protein (R7BP), this theory is challenged by the observations that endogenous R7BP is palmitoylated, co-localizes strongly with the plasma membrane, and has never been identified in the cytosol or nucleus of native neurons or untreated cultured cells. We show here mutant RGS7 lacking the N-terminal Disheveled, EGL-10, Pleckstrin homology domain is expressed in transfected cells but, unlike wild-type RGS7, is excluded from the cell nucleus. As the Disheveled, EGL-10, Pleckstrin homology domain is essential for R7BP binding to RGS7, we studied the subcellular localization of G beta(5) in primary neurons and brain from mice deficient in R7BP. The level of endogenous nuclear G beta(5) and RGS7 in neurons and brains from R7BP knockout mice is reduced by 50-70%. These results suggest that R7BP contributes significantly to the nuclear localization of endogenous G beta(5)/R7-RGS complex in brain."xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2010.06616.x"xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/author | "Zhang J.H."xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/author | "Posokhova E."xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/author | "Simonds W.F."xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/author | "Martemyanov K.A."xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/author | "Gastinger M.J."xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/author | "Panicker L.M."xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/pages | "1101-1112"xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/title | "Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein."xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/20100282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20100282 |
| http://purl.uniprot.org/citations/20100282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20100282 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVV6-mappedCitation-20100282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20100282 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW36-mappedCitation-20100282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20100282 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STC5-mappedCitation-20100282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20100282 |
| http://purl.uniprot.org/uniprot/#_Q3UG14-mappedCitation-20100282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20100282 |
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| http://purl.uniprot.org/uniprot/#_Q8BQP9-mappedCitation-20100282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20100282 |
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| http://purl.uniprot.org/uniprot/#_Q45FE1-mappedCitation-20100282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20100282 |