| http://purl.uniprot.org/citations/2010087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2010087 | http://www.w3.org/2000/01/rdf-schema#comment | "RAP1 is a sequence-specific DNA-binding protein essential for cell growth. The occurrence of RAP1-binding sites in many promoter regions, the mating-type gene silencer elements, and telomeres suggests that RAP1 has multiple functions in the cell. To assess its role in transcription, temperature-sensitive mutations in RAP1 were generated. Analysis of rap1ts strains provides evidence that RAP1 functions in both transcriptional activation and silencing of mating-type genes. Several observations indicate that rap1ts strains are defective in the expression of MAT alpha, whose upstream activation sequence (UAS) contains a RAP1-binding site. At nonpermissive temperatures, decreases in MAT alpha steady-state transcript levels can be detected in MAT alpha rap1ts strains. Furthermore, these strains are deficient in alpha-pheromone production and simultaneously express at least two alpha-specific genes. These phenotypes can be reversed by replacing the RAP1-binding site at MAT alpha with a binding site for the GAL4 transcriptional activator. Certain rap1ts alleles have an opposite effect on the silent mating-type locus HMR, which becomes partially derepressed at nonpermissive temperatures."xsd:string |
| http://purl.uniprot.org/citations/2010087 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.5.4.616"xsd:string |
| http://purl.uniprot.org/citations/2010087 | http://purl.uniprot.org/core/author | "Kurtz S."xsd:string |
| http://purl.uniprot.org/citations/2010087 | http://purl.uniprot.org/core/author | "Shore D."xsd:string |
| http://purl.uniprot.org/citations/2010087 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2010087 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/2010087 | http://purl.uniprot.org/core/pages | "616-628"xsd:string |
| http://purl.uniprot.org/citations/2010087 | http://purl.uniprot.org/core/title | "RAP1 protein activates and silences transcription of mating-type genes in yeast."xsd:string |
| http://purl.uniprot.org/citations/2010087 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/2010087 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2010087 |
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| http://purl.uniprot.org/uniprot/P11938 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2010087 |
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| http://purl.uniprot.org/uniprot/P0CY07 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2010087 |