| http://purl.uniprot.org/citations/20105235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20105235 | http://www.w3.org/2000/01/rdf-schema#comment | "The brain-specific Ras/Rap-GTPase activating protein (SynGAP) is a prime candidate linking N-methyl-d-aspartate receptors to the regulation of the ERK/MAP kinase signalling cascade, suggested to be essential for experience-dependent synaptic plasticity. Here, we evaluated the behavioural phenotype of SynGAP heterozygous knockout mice (SG(+/-)), expressing roughly half the normal levels of SynGAP. In the cognitive domain, SG(+/-) mice demonstrated severe working and reference memory deficits in the radial arm maze task, a mild impairment early in the transfer test of the water maze task, and a deficiency in spontaneous alternation in an elevated T-maze. In the non-cognitive domain, SG(+/-) mice were hyperactive in the open field and appeared less anxious in the elevated plus maze test. In contrast, object recognition memory performance was not impaired in SG(+/-) mice. The reduction in SynGAP thus resulted in multiple behavioural traits suggestive of aberrant cognitive and non-cognitive processes normally mediated by the hippocampus. Immunohistochemical evaluation further revealed a significant reduction in calbindin-positive interneurons in the hippocampus and doublecortin-positive neurons in the dentate gyrus of adult SG(+/-) mice. Heterozygous constitutive deletion of SynGAP is therefore associated with notable behavioural as well as morphological phenotypes indicative of hippocampal dysfunction. Any suggestion of a possible causal link between them however remains a matter for further investigation."xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2010.07079.x"xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/author | "Feldon J."xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/author | "Knuesel I."xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/author | "Muhia M."xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/author | "Yee B.K."xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/author | "Markopoulos F."xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/pages | "529-543"xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/title | "Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP."xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/20105235 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20105235 |
| http://purl.uniprot.org/citations/20105235 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20105235 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVS6-mappedCitation-20105235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20105235 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUM2-mappedCitation-20105235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20105235 |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YUZ2-mappedCitation-20105235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20105235 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUZ5-mappedCitation-20105235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20105235 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV63-mappedCitation-20105235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20105235 |
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| http://purl.uniprot.org/uniprot/#_A0A2S1B6F9-mappedCitation-20105235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20105235 |
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| http://purl.uniprot.org/uniprot/#_A0A140T8K9-mappedCitation-20105235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20105235 |