| http://purl.uniprot.org/citations/20106730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20106730 | http://www.w3.org/2000/01/rdf-schema#comment | "The Prep1 homeodomain transcription factor is essential for embryonic development. 25% of hypomorphic Prep1(i/i) embryos, expressing the gene at 2% of the normal levels, survive pregnancy and live a normal-length life. Later in life, however, these mice develop spontaneous pre-tumoral lesions or solid tumors (lymphomas and carcinomas). In addition, transplantation of E14.5 fetal liver (FL) Prep1(i/i) cells into lethally irradiated mice induces lymphomas. In agreement with the above data, haploinsufficiency of a different Prep1-deficient (null) allele accelerates EmuMyc lymphoma growth. Therefore Prep1 has a tumor suppressor function in mice. Immunohistochemistry on tissue micrroarrays (TMA) generated from three distinct human cohorts comprising a total of some 1000 human tumors revealed that 70% of the tumors express no or extremely low levels of Prep1, unlike normal tissues. Our data in mice are thus potentially relevant to human cancer."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molonc.2010.01.001"xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Blasi F."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Di Fiore P.P."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Bianchi F."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Nuciforo P."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Longobardi E."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Doglioni C."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Ponzoni M."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Lenti E."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Caniatti M."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Iotti G."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Di Rosa P."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Fernandez-Diaz L.C."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Micali N."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/author | "Mejetta S."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/name | "Mol Oncol"xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/pages | "126-134"xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/title | "Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1."xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/20106730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20106730 |
| http://purl.uniprot.org/citations/20106730 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20106730 |
| http://purl.uniprot.org/uniprot/#_B4DGV5-mappedCitation-20106730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20106730 |