| http://purl.uniprot.org/citations/20108321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20108321 | http://www.w3.org/2000/01/rdf-schema#comment | "Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature muscle fibres in vivo, nesprin-2 partly replaced nesprin-1 at the nuclear envelope and short nesprin isoforms became dominant. Sun1 and Sun2 proteins remained unchanged during this fibre maturation. In emerin-negative skin fibroblasts, nesprin-2-giant was relocated from the nuclear envelope to the cytoplasm, not to the endoplasmic reticulum, while nesprin-1 remained at the nuclear envelope. In emerin-negative keratinocytes lacking nesprin-1, nesprin-2 remained at the nuclear envelope. HeLa cell nuclear envelopes lacked nesprin-1, which was the dominant form in myoblasts, while a novel 130-kD nesprin-2 isoform dominated Ntera-2 cells. The results suggest the possibility of isoform-specific and tissue-specific roles for nesprins in nuclear positioning."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.22229"xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/author | "Sewry C.A."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/author | "McNally E.M."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/author | "Morris G.E."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/author | "Wehnert M."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/author | "Furling D."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/author | "Puckelwartz M."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/author | "Lam l.e. T."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/author | "Randles K.N."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/pages | "998-1009"xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/title | "Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development."xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://purl.uniprot.org/core/volume | "239"xsd:string |
| http://purl.uniprot.org/citations/20108321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20108321 |
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