| http://purl.uniprot.org/citations/20109102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20109102 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study performed proteomic analysis of the midbrain and striatum of 6-hydroxydopamine (6-OHDA)-treated neonatal rats--a model of attention-deficit hyperactivity disorder (ADHD). Proteomic analysis revealed that a 58-kDa glucose-regulated protein (Grp58) was temporarily phosphorylated and its level was elevated by 6-OHDA. Furthermore, 6-OHDA increased the expression level of C/EBP homologous protein (CHOP), a mediator of endoplasmic reticulum (ER) stress response, in the midbrain and striatum. In vitro experiments using PC12 cells revealed that 6-OHDA or hydrogen peroxide could induce the elevation of Grp58 and CHOP. 6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA. Collectively, these findings suggest that ER stress involving the alteration of Grp58 and CHOP play a significant role in the induction of insults by 6-OHDA in vivo."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.org/dc/terms/identifier | "doi:10.3109/10715760903536349"xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Horie M."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Yoshida Y."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Nishio K."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Ashida H."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Kinumi T."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Masuo Y."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Niki E."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/author | "Akazawa Y.O."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/name | "Free Radic Res"xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/pages | "410-421"xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/title | "Proteomic characterization of the striatum and midbrain treated with 6-hydroxydopamine: alteration of 58-kDa glucose-regulated protein and C/EBP homologous protein."xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/20109102 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20109102 |
| http://purl.uniprot.org/citations/20109102 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20109102 |
| http://purl.uniprot.org/uniprot/#_A6HPP0-mappedCitation-20109102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20109102 |
| http://purl.uniprot.org/uniprot/#_A6HPP1-mappedCitation-20109102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20109102 |
| http://purl.uniprot.org/uniprot/#_Q62804-mappedCitation-20109102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20109102 |
| http://purl.uniprot.org/uniprot/#_P11598-mappedCitation-20109102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20109102 |
| http://purl.uniprot.org/uniprot/#_Q496Y7-mappedCitation-20109102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20109102 |
| http://purl.uniprot.org/uniprot/#_Q62857-mappedCitation-20109102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20109102 |