| http://purl.uniprot.org/citations/20110345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20110345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20110345 | http://www.w3.org/2000/01/rdf-schema#comment | "Rad17 is critical for the ATR-dependent activation of Chk1 during checkpoint responses. It is known that Rad17 loads the Rad9-Hus1-Rad1 (9-1-1) complex onto DNA. We show that Rad17 also mediates the interaction of 9-1-1 with the ATR-activating protein TopBP1 in Xenopus egg extracts. Studies with Rad17 mutants indicate that binding of ATP to Rad17 is essential for the association of 9-1-1 and TopBP1. Furthermore, hydrolysis of ATP by Rad17 is necessary for the loading of 9-1-1 onto DNA and the elevated, checkpoint-dependent accumulation of TopBP1 on chromatin. Significantly, a mutant 9-1-1 complex that cannot bind TopBP1 has a normal capacity to promote elevated accumulation of TopBP1 on chromatin. Taken together, we propose the following mechanism. First, Rad17 loads 9-1-1 onto DNA. Second, TopBP1 accumulates on chromatin in a manner that depends on both Rad17 and 9-1-1. Finally, 9-1-1 and TopBP1 dock in a Rad17-dependent manner before activation of Chk1."xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e09-11-0958"xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/author | "Dunphy W.G."xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/author | "Dunphy W.G."xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/pages | "926-935"xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/pages | "926-935"xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/title | "Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks."xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/title | "Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks."xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/20110345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20110345 |
| http://purl.uniprot.org/citations/20110345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20110345 |
| http://purl.uniprot.org/citations/20110345 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20110345 |
| http://purl.uniprot.org/citations/20110345 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20110345 |
| http://purl.uniprot.org/uniprot/Q8AY27 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/20110345 |
| http://purl.uniprot.org/uniprot/Q7ZZU5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/20110345 |
| http://purl.uniprot.org/uniprot/Q6INE0 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/20110345 |