| http://purl.uniprot.org/citations/20111005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20111005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20111005 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular signalling cascades regulate the activity of transcription factors that convert extracellular information into gene regulation. C/EBPbeta is a ras/MAPkinase signal-sensitive transcription factor that regulates genes involved in metabolism, proliferation, differentiation, immunity, senescence, and tumourigenesis. The protein arginine methyltransferase 4 PRMT4/CARM1 interacts with C/EBPbeta and dimethylates a conserved arginine residue (R3) in the C/EBPbeta N-terminal transactivation domain, as identified by mass spectrometry of cell-derived C/EBPbeta. Phosphorylation of the C/EBPbeta regulatory domain by ras/MAPkinase signalling abrogates the interaction between C/EBPbeta and PRMT4/CARM1. Differential proteomic screening, protein interaction studies, and mutational analysis revealed that methylation of R3 constraines interaction with SWI/SNF and Mediator complexes. Mutation of the R3 methylation site alters endogenous myeloid gene expression and adipogenic differentiation. Thus, phosphorylation of the transcription factor C/EBPbeta couples ras signalling to arginine methylation and regulates the interaction of C/EBPbeta with epigenetic gene regulatory protein complexes during cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.3"xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.3"xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Leutz A."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Leutz A."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Pless O."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Pless O."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Dittmar G."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Dittmar G."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Knoblich M."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Knoblich M."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Kowenz-Leutz E."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/author | "Kowenz-Leutz E."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/pages | "1105-1115"xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/pages | "1105-1115"xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/title | "Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/title | "Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code."xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20111005 | http://purl.uniprot.org/core/volume | "29"xsd:string |