| http://purl.uniprot.org/citations/20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20111728 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that the -2518 MCP-1 genotype GG increases the likelihood of developing tuberculosis (TB) in non-BCG-vaccinated Mexicans and Koreans. Here, we tested the hypothesis that this genotype, alone or together with the -1607 MMP-1 functional polymorphism, increases the likelihood of developing TB in BCG-vaccinated individuals. We conducted population-based case-control studies of BCG-vaccinated individuals in Mexico and Peru that included 193 TB cases and 243 healthy tuberculin-positive controls from Mexico and 701 TB cases and 796 controls from Peru. We also performed immunohistochemistry (IHC) analysis of lymph nodes from carriers of relevant two-locus genotypes and in vitro studies to determine how these variants may operate to increase the risk of developing active disease. We report that a joint effect between the -2518 MCP-1 genotype GG and the -1607 MMP-1 genotype 2G/2G consistently increases the odds of developing TB 3.59-fold in Mexicans and 3.9-fold in Peruvians. IHC analysis of lymph nodes indicated that carriers of the two-locus genotype MCP-1 GG MMP-1 2G/2G express the highest levels of both MCP-1 and MMP-1. Carriers of these susceptibility genotypes might be at increased risk of developing TB because they produce high levels of MCP-1, which enhances the induction of MMP-1 production by M. tuberculosis-sonicate antigens to higher levels than in carriers of the other two-locus MCP-1 MMP-1 genotypes studied. This notion was supported by in vitro experiments and luciferase based promoter activity assay. MMP-1 may destabilize granuloma formation and promote tissue damage and disease progression early in the infection. Our findings may foster the development of new and personalized therapeutic approaches targeting MCP-1 and/or MMP-1."xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0008881"xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/author | "Flores-Villanueva P.O."xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/author | "Granados J."xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/author | "Ruiz-Morales J.A."xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/author | "Ganachari M."xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/author | "Dinh J."xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/author | "Gomez de la Torre Pretell J.C."xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/pages | "e8881"xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/title | "Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals."xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/20111728 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20111728 |
| http://purl.uniprot.org/citations/20111728 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20111728 |
| http://purl.uniprot.org/uniprot/#_A5GZ69-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |
| http://purl.uniprot.org/uniprot/#_B4DN15-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |
| http://purl.uniprot.org/uniprot/#_B4DW26-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |
| http://purl.uniprot.org/uniprot/#_L8EC95-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |
| http://purl.uniprot.org/uniprot/#_J3KRT7-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |
| http://purl.uniprot.org/uniprot/#_Q53G95-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |
| http://purl.uniprot.org/uniprot/#_Q53G96-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |
| http://purl.uniprot.org/uniprot/#_Q53G97-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |
| http://purl.uniprot.org/uniprot/#_P03956-mappedCitation-20111728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111728 |