| http://purl.uniprot.org/citations/20111892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20111892 | http://www.w3.org/2000/01/rdf-schema#comment | "p66Shc, a 66 kDa proto-oncogene Src homologous-collagen homologue (Shc) adaptor protein, is classically known in mediating receptor tyrosine kinase signaling and recently identified as a sensor to oxidative stress-induced apoptosis and as a longevity protein in mammals. The expression of p66Shc is decreased in mice and increased in human fibroblasts upon aging and in aging-related diseases, including prostate cancer. p66Shc protein level correlates with the proliferation of several carcinoma cells and can be regulated by steroid hormones. Recent advances point that p66Shc protein plays a role in mediating cross-talk between steroid hormones and redox signals by serving as a common convergence point in signaling pathways on cell proliferation and apoptosis. This article first reviews the unique function of p66Shc protein in regulating oxidative stress-induced apoptosis. Subsequently, we discuss its novel role in androgen-regulated prostate cancer cell proliferation and metastasis and the mechanism by which it mediates androgen action via the redox signaling pathway. The data together indicate that p66Shc might be a useful biomarker for the prognosis of prostate cancer and serve as an effective target for its cancer treatment."xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10555-010-9213-8"xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/author | "Lin M.F."xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/author | "Rajendran M."xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/author | "Veeramani S."xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/author | "Thomes P."xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/name | "Cancer Metastasis Rev"xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/pages | "207-222"xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/title | "p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis."xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20111892 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20111892 |
| http://purl.uniprot.org/citations/20111892 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20111892 |
| http://purl.uniprot.org/uniprot/#_B4DL02-mappedCitation-20111892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111892 |
| http://purl.uniprot.org/uniprot/#_P29353-mappedCitation-20111892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111892 |
| http://purl.uniprot.org/uniprot/#_Q59HB0-mappedCitation-20111892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111892 |
| http://purl.uniprot.org/uniprot/#_Q8NFT0-mappedCitation-20111892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20111892 |
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| http://purl.uniprot.org/uniprot/Q8NFT0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20111892 |
| http://purl.uniprot.org/uniprot/Q8NFT1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20111892 |