| http://purl.uniprot.org/citations/2011584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2011584 | http://www.w3.org/2000/01/rdf-schema#comment | "Ligation of membrane IgM on B lymphocytes causes activation of a protein-tyrosine kinase(s) (PTK) and of phospholipase C (PLC). To determine whether these are elements of a common signal-transduction pathway, the effect of three PTK inhibitors on the rise in intracellular free Ca2+ concentration [( Ca2+]i) in human B-lymphoblastoid cell lines was assessed. Tyrphostin completely suppressed the increase in [Ca2+]i and the generation of inositol phosphates induced by ligation of membrane immunoglobulin (mIg) M. Herbimycin and genistein reduced by 30% and 50%, respectively, the rise in [Ca2+]i caused by optimal ligation of mIgM, and they abolished it in cells activated by suboptimal ligation of mIgM. Tyrphostin had no effect on the capacity of aluminum fluoride to increase [Ca2+]i. To determine whether a function of PTK is the phosphorylation of PLC, immunoprecipitates obtained with anti-phosphotyrosine from detergent lysates of B-lymphoblastoid cells were assayed for PLC activity. Ligation of mIgM increased immunoprecipitable PLC activity 2-fold by 90 sec and 4-fold by 30 min. Specific immunoprecipitation and Western blot analysis identified tyrosine phosphorylation of the gamma 1 isoform of PLC after 60 sec of stimulation. Activation of PLC in B cells by mIgM requires PTK function and is associated with tyrosine phosphorylation of PLC-gamma 1, suggesting a mechanism of PLC activation similar to that described for certain receptor PTKs."xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.88.7.2745"xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/author | "Rhee S.G."xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/author | "Park D.J."xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/author | "Carter R.H."xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/author | "Fearon D.T."xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/pages | "2745-2749"xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/title | "Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/2011584 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2011584 |
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