| http://purl.uniprot.org/citations/20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20126553 | http://www.w3.org/2000/01/rdf-schema#comment | "The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy by controlling the mammalian translational machinery via phosphorylation of S6K1 and 4E-BP1. mTOR and S6K1 are connected by interacting with the eIF3 initiation complex. The regulatory subunit eIF3f plays a major role in muscle hypertrophy and is a key target that accounts for MAFbx function during atrophy. Here we present evidence that in MAFbx-induced atrophy the degradation of eIF3f suppresses S6K1 activation by mTOR, whereas an eIF3f mutant insensitive to MAFbx polyubiquitination maintained persistent phosphorylation of S6K1 and rpS6. During terminal muscle differentiation a conserved TOS motif in eIF3f connects mTOR/raptor complex, which phosphorylates S6K1 and regulates downstream effectors of mTOR and Cap-dependent translation initiation. Thus eIF3f plays a major role for proper activity of mTORC1 to regulate skeletal muscle size."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0008994"xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/author | "Poupon A."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/author | "Csibi A."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/author | "Leibovitch M.P."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/author | "Leibovitch S.A."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/author | "Tintignac L.A."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/author | "Cornille K."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/author | "Sanchez A.M."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/pages | "e8994"xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/title | "The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse."xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/20126553 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20126553 |
| http://purl.uniprot.org/citations/20126553 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20126553 |
| http://purl.uniprot.org/uniprot/#_B0LAD0-mappedCitation-20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20126553 |
| http://purl.uniprot.org/uniprot/#_P62754-mappedCitation-20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20126553 |
| http://purl.uniprot.org/uniprot/#_Q925G8-mappedCitation-20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20126553 |
| http://purl.uniprot.org/uniprot/#_O35670-mappedCitation-20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20126553 |
| http://purl.uniprot.org/uniprot/#_Q3U8X1-mappedCitation-20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20126553 |
| http://purl.uniprot.org/uniprot/#_Q8BSK8-mappedCitation-20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20126553 |
| http://purl.uniprot.org/uniprot/#_Q8BTW2-mappedCitation-20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20126553 |
| http://purl.uniprot.org/uniprot/#_Q3UVY8-mappedCitation-20126553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20126553 |