| http://purl.uniprot.org/citations/20128678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20128678 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, epithelial-mesenchymal transition (EMT) has been reported to contribute to tissue fibrosis through enhanced transforming growth factor (TGF)-beta1 signaling. Tumor necrosis factor (TNF)-alpha has also been implicated in tissue fibrosis. Therefore, the authors investigated whether TNF-alpha affected TGF-beta1-induced EMT. Cultured alveolar epithelial cells (A549 cells) were stimulated with TGF-beta1 (5 ng/mL), with/without TNF-alpha (10 ng/mL). TGF-beta1 induced EMT of A549 cells, with loss of E-cadherin and acquisition of vimentin. Combination of TNF-alpha with TGF-beta1 enhanced EMT, causing morphological changes, while quantitative polymerase chain reaction (PCR) showed suppression of E-cadherin mRNA and expression of vimentin mRNA. In addition, the gel contraction method revealed that cells that had undergone EMT acquired cell contractility, which is a feature of mesenchymal cells. Stimulation with TGF-beta1 induced cell contraction, as did TNF-alpha. Moreover, costimulation with TGF-beta1 and TNF-alpha enhanced the cell contraction. Although IFN-gamma suppressed spontaneous cell contraction, it did not suppress cell contraction, which was induced by TGF-beta1. In conclusion, TNF-alpha enhances not only EMT but also cell contraction induced by TGF-beta1. EMT might contribute to tissue fibrosis through induction of cell contraction."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.org/dc/terms/identifier | "doi:10.3109/01902140903042589"xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Nagase T."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Yamauchi Y."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Kato J."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Kamitani S."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Kawasaki S."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Takami K."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Takizawa H."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Kohyama T."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/author | "Desaki M."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/name | "Exp Lung Res"xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/pages | "12-24"xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/title | "Tumor necrosis factor-alpha enhances both epithelial-mesenchymal transition and cell contraction induced in A549 human alveolar epithelial cells by transforming growth factor-beta1."xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/20128678 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20128678 |
| http://purl.uniprot.org/citations/20128678 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20128678 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-20128678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20128678 |
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| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-20128678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20128678 |
| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-20128678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20128678 |
| http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-20128678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20128678 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-20128678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20128678 |