| http://purl.uniprot.org/citations/20129061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20129061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20129061 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine of key importance for controlling embryogenesis and tissue homeostasis. How TGF-beta signals are attenuated and terminated is not well understood. Here, we show that TMEPAI, a direct target gene of TGF-beta signaling, antagonizes TGF-beta signaling by interfering with TGF-beta type I receptor (TbetaRI)-induced R-Smad phosphorylation. TMEPAI can directly interact with R-Smads via a Smad interaction motif. TMEPAI competes with Smad anchor for receptor activation for R-Smad binding, thereby sequestering R-Smads from TbetaRI kinase activation. In mammalian cells, ectopic expression of TMEPAI inhibited TGF-beta-dependent regulation of plasminogen activator inhibitor-1, JunB, cyclin-dependent kinase inhibitors, and c-myc expression, whereas specific knockdown of TMEPAI expression prolonged duration of TGF-beta-induced Smad2 and Smad3 phosphorylation and concomitantly potentiated cellular responsiveness to TGF-beta. Consistently, TMEPAI inhibits activin-mediated mesoderm formation in Xenopus embryos. Therefore, TMEPAI participates in a negative feedback loop to control the duration and intensity of TGF-beta/Smad signaling."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.10.028"xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.10.028"xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Goto T."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Goto T."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Nakano N."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Nakano N."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Satoh K."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Satoh K."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Tanaka A."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Tanaka A."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Mommaas A.M."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Mommaas A.M."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Shi L."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Shi L."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Itoh S."xsd:string |
| http://purl.uniprot.org/citations/20129061 | http://purl.uniprot.org/core/author | "Itoh S."xsd:string |