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http://purl.uniprot.org/citations/20137308http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20137308http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To explore the relationship between CMV reactivation and KIR haplotype or HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation (HSCT).

Methods

From January 2003 to December 2008 the HLA-Cw/KIR genotype of 48 patient-donor pairs were determined by polymerase chain reaction with sequence specific primers (PCR-SSP) and sequence specific nucleotide (PCR-SSOP). Posttransplant CMV reactivation was performed by immune histochemically assay.

Results

Of 48 patients, 15 were transplanted from unrelated donors with an antigen mismatch for HLA Cw and 33 patient-donor pairs were matched for HLA-Cw. The CMV reaction rate was 66.7% for HLA-Cw mismatch group and 48.5% for HLA-Cw match group (chi(2) = 1.39, P = 0.2375). Thirty-seven donor-patients pairs belonged to group C1 and 11 to group C2, and CMV reaction rate was 64.9% in group C1 and 18.2% in group C2 (chi(2) = 18.13, P < 0.0001). Twenty-six patients received graft from KIR haplotype A (group A donor) and 22 from KIR haplotype B donors (group B donor) and CMV reaction rate was 57.7% in group A donor and 50.0% in group B donor (chi(2) = 0.28, P = 0.5941). The number of donor activating KIRs (aKIRs) was less than that of recipient aKIRs in 34 patient-donor pairs in which the CMV reaction rate was 70.6%, and the number of donor aKIRs was more than that of recipient aKIRs in 14 patient-donor pairs in which the CMV reactivation was 14.3%. There was a significan difference between the two group (chi(2) = 12.44, P = 0.0004).

Conclusion

KIR and HLA-Cw genotypes influence the rate of CMV reactivation following non-T cell deleted unrelated donor hematopoietic cell transplantation."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Han Y."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"He J."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Ma X."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Xu Y."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Wu X.J."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Feng Y.F."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Li W.Y."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Chang H.R."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Zhu Z.L."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Dai L.J."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Yuan X.N."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Wu D.P."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Sun A.N."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Bao X.J."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/author"Qiu Q.C."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/name"Zhonghua Xue Ye Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/pages"741-744"xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/title"[Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.]."xsd:string
http://purl.uniprot.org/citations/20137308http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/20137308http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20137308
http://purl.uniprot.org/citations/20137308http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20137308
http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-20137308http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20137308
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