| http://purl.uniprot.org/citations/20141835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20141835 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent BRAF binding to CRAF, CRAF activation, and MEK-ERK signaling. This does not occur when oncogenic BRAF is inhibited, demonstrating that BRAF inhibition per se does not drive pathway activation; it only occurs when BRAF is inhibited in the presence of oncogenic RAS. Kinase-dead BRAF mimics the effects of the BRAF-selective drugs and kinase-dead Braf and oncogenic Ras cooperate to induce melanoma in mice. Our data reveal another paradigm of BRAF-mediated signaling that promotes tumor progression. They highlight the importance of understanding pathway signaling in clinical practice and of genotyping tumors prior to administering BRAF-selective drugs, to identify patients who are likely to respond and also to identify patients who may experience adverse effects."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.12.040"xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Hussain J."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Marais R."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Reis-Filho J.S."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Pritchard C."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Whittaker S."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Springer C.J."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Dhomen N."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Heidorn S.J."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Milagre C."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Niculescu-Duvas I."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/author | "Nourry A."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/pages | "209-221"xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/title | "Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF."xsd:string |
| http://purl.uniprot.org/citations/20141835 | http://purl.uniprot.org/core/volume | "140"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0N4SWH5-mappedCitation-20141835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20141835 |
| http://purl.uniprot.org/uniprot/#_P10398-mappedCitation-20141835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20141835 |